OBTAINING AND ASSESSING IMMUNOGENICITY OF A FUSION PROTEIN WHICH CONSISTS OF A RECEPTOR-BINDING DOMAIN (RBD) OF CORONAVIRUS SARS-COV-2 SPIKE PROTEIN AND A MONOMERIC NON- GLYCOSYLATED FC-FRAGMENT OF HUMAN IGG1

A.Yu. Ryazanova,N.A. Orlova, M.V. Sinegubova, L.K. Dayanova, S.V. Kovnir, S.V. Korobova, V.A. Ledov, A.L. Kovalchuk, P.G. Aparin, I.I. Vorobiev

BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES（2022）

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摘要

Variants of genetic constructions are discussed which encode a receptor-binding domain (RBD) of coronavirus SARS-CoV-2 spike protein fused with a monomeric Fc-fragment of human immunoglobulins. A cell line producing RBD-Fc is established. High titers of anti-RBD antibodies and virus-neutralizing antibodies are obtained upon mice immunization with the purified RBD-Fc.

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