Spent Culture Supernatant of Streptococcus gordonii Mitigates Inflammation of Human Periodontal Cells and Inhibits Proliferation of Pathogenic Oral Microbes.

These results strongly suggest that S. gordonii-derived SCS contains metabolites that have anti-inflammatory properties and an ability to inhibit periodontitis-associated pathogenic bacteria. Further investigation will be needed to identify the individual metabolites within the Sg-SCS in order to develop a novel metabolite-based approach to treating and preventing periodontitis. This article is protected by copyright. All rights reserved.