The Role of Sumoylation in Mammalian Embryonic Development and Organogenesis br

Small ubiquitin-related modifier protein(SUMO)modification is a kind of widespread form of post-translational modification.It exists in multiple physiological and pathological processes,and is involved in anumber of signal transduction pathways.Sumoylation is one of the important regulating mechanism in the cellularresponse to stress,and a growing body of research suggests that the SUMO play an important role in the processof embryonic development and organogenesis in mammals.Sumoylation plays an important role in the formationand development of organs in fetal development.The components of the sumoylation pathway(UBC9,SUMO1-3,PIAS,SENP1-7)play important roles in the coordination of the dialogue between the blastocyst and the uterus,the development of the heart,and craniofacial development.When these developmental dysfunctions occur,theycan lead to preimplantation defects,developmental defects,and fetal death.In this review,we will focus on recentadvances in this field,summarizing the important roles in early embryonic development and organogenesis ofSUMO,UBC9,PIAS,and SENPs,which have been linked to the SUMO pathway,and the consequences ofaberrant SUMOylation,to provide a reference for future research