Butyrate Attenuates Hepatic Steatosis Induced by a High-Fat and Fiber-Deficient Diet via the Hepatic GPR41/43-CaMKII/HDAC1-CREB Pathway.

Mingxuan Zheng,Xiaoying Yang, Qingyuan Wu,Yuying Gong,Ning Pang,Xing Ge,Nathan Nagaratnam,Pengfei Jiang,Menglu Zhou,Tao Hu,Hui Hua,Kuiyang Zheng,Xu-Feng Huang,Yinghua Yu

Molecular nutrition & food research（2023）

引用 4|浏览17

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摘要

This work reveals that butyrate improves hepatic lipid metabolism through the GPR41/43-CaMKII/HDAC1-CREB pathway, providing support for consideration of butyrate as a dietary supplement to prevent the progression of NAFLD induced by the Western-style diet.

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关键词

CREB,CaMKII,GPR41,GPR43,HDAC1,NAFLD,butyrate

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