Ocular Biomarkers for Alzheimer Disease Dementia: An Umbrella Review of Systematic Reviews and Meta-analyses.

Eliana Costanzo,Imre Lengyel,Mariacristina Parravano,Ilaria Biagini,Michele Veldsman,AmanPreet Badhwar,Matthew Betts,Antonio Cherubini,David J Llewellyn,Ilianna Lourida,Tom MacGillivray,Timothy Rittman,Stefano Tamburin,Xin You Tai,Gianni Virgili

JAMA ophthalmology（2022）

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摘要

This umbrella review has highlighted limitations in design and reporting of the existing research on ocular biomarkers for diagnosing AD. Parameters with the best evidence showed poor to moderate diagnostic accuracy in cross-sectional studies. Future longitudinal studies should investigate whether changes in OCT and OCTA measurements over time can yield accurate predictions of AD onset.

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