Matrine suppresses NLRP3 inflammasome activation via regulating PTPN2/JNK/SREBP2 pathway in sepsis

Xu Wang, Fu-Peng Wu,Yu-Ran Huang,Hai-Dong Li,Xin-Yue Cao,Yan You,Zhe-Feng Meng,Ke-Yu Sun,Xiao-Yan Shen

Phytomedicine（2022）

引用 6|浏览5

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摘要

•Matrine improved the symptoms of CLP-induced sepsis mice.•Matrine reduced the levels of inflammatory factors in CLP-induced sepsis mice.•Matrine inhibited pyroptosis in THP-1 cells stimulated by nigericin or ATP.•Matrine suppressed NLRP3 inflammasome activation through regulating PTPN2/JNK/SREBP2 pathway.

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关键词

Macrophages,Pyroptosis,CLP-induced sepsis,Matrine,PTPN2/JNK/SREBP2

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