LQFM212, a piperazine derivative, exhibits potential antioxidant effect as well as ameliorates LPS-induced behavioral, inflammatory and oxidative changes

Lorrane Kelle da Silva Moreira,Larissa Córdova Turones,Hericles Mesquita Campos, Aline Martins Nazareth,Douglas Vieira Thomaz,Eric de Souza Gil,Paulo César Ghedini,Fábio Fagundes da Rocha,Ricardo Menegatti,James Oluwagbamigbe Fajemiroye,Elson Alves Costa

Life Sciences（2023）

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摘要

LQFM212 presents antioxidant activity and ameliorates behavioral, inflammatory and oxidative changes after LPS-induced neuroinflammation model. These effects do not seem to be secondary to a peripheral anti-inflammatory action of LQFM212, since this compound failed to attenuate the inflammatory changes in LPS-induced pleurisy model.

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关键词

Neuroinflammation,Oxidative stress,Cytokines,Depressive behavior

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