Distinct Mechanisms of β-Arrestin-Biased Agonist and Blocker of AT1R in Preventing Aortic Aneurysm and Associated Mortality.

Zaira Palomino Jara,Terri J Harford,Khuraijam Dhanachandra Singh,Russell Desnoyer,Avinash Kumar,Dasarathy Srinivasan,Sadashiva S Karnik

Hypertension (Dallas, Tex. : 1979)（2023）

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摘要

TRV027-engaged AT1R prevented AA and associated mortality by distinct molecular mechanisms compared with the AT1R blocker, Olmesartan. Developing novel β-arrestin-biased AT1R ligands may yield promising drugs to combat AA.

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关键词

aortic aneurysm,arrestin,biased ligand,cell proliferation,proteostasis,receptor, AT1R,β

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