NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload.

Yasutomi Higashikuni,Wenhao Liu,Genri Numata,Kimie Tanaka,Daiju Fukuda,Yu Tanaka,Yoichiro Hirata,Teruhiko Imamura,Eiki Takimoto,Issei Komuro,Masataka Sata

Circulation（2023）

引用 26|浏览21

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摘要

Cardiac inflammation and hypertrophy are regulated by heart-brain interaction. Controlling neural signals might be important for the treatment of hypertensive heart disease.

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关键词

NLR family, pyrin domain-containing 3 protein,adenosine triphosphate,cardiomegaly,inflammasomes,nervous system,receptors, purinergic P2X7

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