Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway.

Expert opinion on drug delivery(2023)

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摘要
Our findings prove the therapeutic efficacy of CH NE at a lower dose which could be a potential brain targeting platform to combat epilepsy.
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关键词
AMPK/SIRT-1/PGC-1α,chrysin,microglia polarization,nanoemulsion,oxidative stress,status epilepticus
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