Peering into the Molecular Machinery for Regulation of Cav1.2 Channel Clusters.

HomeCirculation ResearchVol. 131, No. 12Peering into the Molecular Machinery for Regulation of Cav1.2 Channel Clusters No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextPeering into the Molecular Machinery for Regulation of Cav1.2 Channel Clusters Drew M. Nassal and Thomas J. Hund Drew M. NassalDrew M. Nassal https://orcid.org/0000-0002-8018-3913 The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (D.M.N., T.J.H.). Departments of Internal Medicine and Biomedical Engineering, The Ohio State University, Columbus (D.M.N., T.J.H.). Search for more papers by this author and Thomas J. HundThomas J. Hund Correspondence to: Thomas J. Hund, PhD, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Avenue, Columbus, OH 43210. Email E-mail Address: [email protected] https://orcid.org/0000-0002-9957-7306 The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (D.M.N., T.J.H.). Departments of Internal Medicine and Biomedical Engineering, The Ohio State University, Columbus (D.M.N., T.J.H.). Search for more papers by this author Originally published1 Dec 2022https://doi.org/10.1161/CIRCRESAHA.122.322131Circulation Research. 2022;131:1034–1036This article is a commentary on the followingSpatiotemporal Control of Vascular CaV1.2 by α1C S1928 PhosphorylationFootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Sources of Funding and Disclosures, see page 1036.Correspondence to: Thomas J. Hund, PhD, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Avenue, Columbus, OH 43210. Email thomas.[email protected]eduReferences1. Baudel M, Flores-Tamez VA, Hong J, Reddy GR, Maillard P, Burns AE, Man KN, Sasse KC, Ward SM, Catterall WA, et al. Spatiotemporal control of vascular Cav1.2 by α1c S1928 phosphorylation.Circ Res. 2022; 131:1018–1033. doi: 10.1161/CIRCRESAHA.122.321479.LinkGoogle Scholar2. Catterall W. Structure and regulation of voltage-gated Ca2+ channels.Annu Rev Cell Dev Biol. 2000; 16:521–555. doi: 10.1146/annurev.cellbio.16.1.521CrossrefMedlineGoogle Scholar3. Catterall WA. Voltage-gated calcium channels.Cold Spring Harb Perspect Biol. 2011; 3:a003947. doi: 10.1101/cshperspect.a003947CrossrefMedlineGoogle Scholar4. Dolphin AC. Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology.J Physiol. 2016; 594:5369–5390. doi: 10.1113/JP272262CrossrefMedlineGoogle Scholar5. Navedo MF, Amberg GC, Votaw VS, Santana LF. Constitutively active L-type Ca2+ channels.Proc Natl Acad Sci USA. 2005; 102:11112–11117. doi: 10.1073/pnas.0500360102CrossrefMedlineGoogle Scholar6. Navedo MF, Amberg GC, Nieves M, Molkentin JD, Santana LF. Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle.J Gen Physiol. 2006; 127:611–622. doi: 10.1085/jgp.200609519CrossrefMedlineGoogle Scholar7. Inoue M, Bridge JH. Ca2+ sparks in rabbit ventricular myocytes evoked by action potentials: involvement of clusters of L-type Ca2+ channels.Circ Res. 2003; 92:532–538. doi: 10.1161/01.RES.0000064175.70693.ECLinkGoogle Scholar8. Pfeiffer P, Egorov AV, Lorenz F, Schleimer JH, Draguhn A, Schreiber S. Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory.Elife. 2020; 9:e49974. doi: 10.7554/eLife.49974CrossrefMedlineGoogle Scholar9. Dixon RE, Moreno CM, Yuan C, Opitz-Araya X, Binder MD, Navedo MF, Santana LF. Graded Ca(2)(+)/calmodulin-dependent coupling of voltage-gated CaV1.2 channels.Elife2015; 4:e05608. doi: 10.7554/eLife.05608CrossrefMedlineGoogle Scholar10. Prada MP, Syed AU, Reddy GR, Martin-Aragon Baudel M, Flores-Tamez VA, Sasse KC, Ward SM, Sirish P, Chiamvimonvat N, Bartels P, et al. AKAP5 complex facilitates purinergic modulation of vascular L-type Ca(2+) channel CaV1.2.Nat Commun. 2020; 11:5303. doi: 10.1038/s41467-020-18947-yCrossrefMedlineGoogle Scholar11. Dixon RE, Navedo MF, Binder MD, Santana LF. Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiol Rev. 2022; 102:1159–1210. doi: 10.1152/physrev.00022.2021CrossrefMedlineGoogle Scholar12. Clatot J, Hoshi M, Wan X, Liu H, Jain A, Shinlapawittayatorn K, Marionneau C, Ficker E, Ha T, Deschenes I. Voltage-gated sodium channels assemble and gate as dimers.Nat Commun. 2017; 8:2077. doi: 10.1038/s41467-017-02262-0CrossrefMedlineGoogle Scholar13. Liu C, Ke P, Zhang J, Zhang X, Chen X. Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A.Front Physiol. 2020; 11:574030. doi: 10.3389/fphys.2020.574030CrossrefMedlineGoogle Scholar14. Bannister JP, Leo MD, Narayanan D, Jangsangthong W, Nair A, Evanson KW, Pachuau J, Gabrick KS, Boop FA, Jaggar JH. The voltage-dependent L-type Ca2+ (CaV1.2) channel C-terminus fragment is a bi-modal vasodilator.J Physiol. 2013; 591:2987–2998. doi: 10.1113/jphysiol.2013.251926CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesSpatiotemporal Control of Vascular CaV1.2 by α1C S1928 PhosphorylationMiguel Martín-Aragón Baudel, et al. Circulation Research. 2022;131:1018-1033 December 2, 2022Vol 131, Issue 12 Advertisement Article InformationMetrics © 2022 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.122.322131PMID: 36454852 Originally publishedDecember 1, 2022 KeywordsEditorialsphosphorylationserinecytoskeletal proteinsgene expressionPDF download Advertisement