Circulating versus cellular tumor DNA for the detection of BTK resistant CLL clones

Arne Trummer, Wiebke Schier,Jürgen Krauter,Horst Hannig,Jens Christmann

Leukemia Research Reports（2022）

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摘要

•Wild-type blocking PCR is a sensitive, cost-effective and routinely applicable method for the detection of BTK resistant CLL clones but misses low frequency mutations when using ctDNA.

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关键词

CLL,ibrutinib,BTK mutation,ctDNA,Wild-type blocking RT-PCR

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