Zn(II) phthalocyanines having fluoroether groups: Synthesis, characterization, photo-physicochemical and biological properties

Tetra non-peripheral and peripheral substituted Zn(II) phthalocyanine (Pc) derivatives bearing 2,2-difluoro-2-[1,1,2,2-tetrafluoro-2-(trifluoromethoxy)ethoxy]ethoxy groups (KH-69, KH-71) were synthesized and characterized to be antioxidant and antimicrobial agents. Photo-physicochemical properties of these compounds were investigated. Then, the DPPH free radical scavenging activity of the Pc derivatives was found as 97.74% and 94.89%, respectively. Both the Pc complexes showed perfect DNA nuclease activity with double strain break against pBR 322 plasmid DNA at 100 mg/L concentration. KH-69 and KH-71indicated good antimicrobial activity against studied Gram-positive and Gram-negative bacteria, and fungal strains. Moreover, the Pcs showed excellent cell viability inhibition activity even at the lowest concentration. These Pc derivatives inhibited P. aeroginasa and S. aureus biofilm formation. The Pcs showed the highest biofilm inhibition with photodynamic therapy against S. aureus and P. aeroginasa with 95.40% and 90.03%, respectively.