HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate.

Christine Jones,Mariano Avino,Véronique Giroux,Francois Boudreau

Cellular and molecular gastroenterology and hepatology（2023）

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摘要

Our results support the intrinsic epithelial role of HNF4α in regulating Paneth cell homeostasis and intestinal epithelium renewal in the absence of compensatory Wnt signaling.

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关键词

Enteroids,HNF4α,Paneth Cells,Wnt3

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