Carbonic Anhydrase IX (CAIX) Expressing Hypoxic Micro-environment Hampers CD8+ Immune Cell Infiltrate in Breast Carcinoma.

Péter Juhász, Dóra Hasulyó,Judit Bedekovics,Lívia Beke, Norbert Kacsala,Miklós Török,Gábor Méhes

Applied immunohistochemistry & molecular morphology : AIMM（2023）

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摘要

Our measurements demonstrate for the first time that tumor areas with CAIX expression potentially hamper CD8+ T-lymphocyte infiltration in breast carcinoma. The hypoxia-driven adaptive micro-environment likely interferes with the specific response to biological and immune therapies requiring intact effector T-cell response.

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关键词

CAIX,micro-environment,breast cancer,tumor-infiltrating lymphocytes (TIL)

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