[The Hematopoietic Protective Effect of PDGF-BB on Radiation-Induced Myelosuppression Model Mice].

Yi Luo,Hui-Min Kong,Wei-Qing Su,Wen-Fang Yi,Hui Ge,Hui Chen,Liang Li,Mo Yang

Zhongguo shi yan xue ye xue za zhi（2022）

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摘要

PDGF-BB has a protective effect on the hematopoietic system of myelosuppression model mice, especially megakaryocytes and their progenitor cells. PDGF-BB has pro-proliferative and anti-apoptotic effects on Meg-01 cells, and the mechanism may be mediated through JC-1 and caspase-3 pathway.

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关键词

Meg-01 cell ,apoptosis ,hematopoietic protection ,platelet-derived growth factor-BB

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