Crosstalk between cytotoxic CD8+ T cells and stressed cardiomyocytes triggers development of interstitial cardiac fibrosis in hypertensive mouse hearts.

Kurt Brassington,Peter Kanellakis,Anh Cao,Ban-Hock Toh,Karlheinz Peter,Alex Bobik,Tin Kyaw

Frontiers in immunology（2022）

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摘要

Our data highlight a novel pathway by which CD8 T cells contribute to an early triggering mechanism in CF development; preventing CD8+ T cell activation by inhibiting the cardiomyocyte RAE-1-CD8+ T cell-NKG2D axis holds promise for novel therapeutic strategies to limit hypertensive cardiac fibrosis.

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关键词

CD8+ T cells,NKG2D,RAE-1,STING,TGF-β1,cardiac fibrosis,cardiomyocytes,perforin

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