Exposure to World Trade Center Dust Exacerbates Cognitive Impairment and Evokes a Central and Peripheral Pro-Inflammatory Transcriptional Profile in an Animal Model of Alzheimer's Disease.

Ruth Iban-Arias,Kyle J Trageser,Eun-Jeong Yang,Elizabeth Griggs,Aurelian Radu,Sean Naughton,Md Al Rahim,Oguchi Tatsunori,Urdhva Raval,Joshua Palmieri, Zerlina Huang,Lung-Chi Chen,Giulio Maria Pasinetti

Journal of Alzheimer's disease : JAD（2023）

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摘要

These studies suggest a putative peripheral-brain immune inflammatory cross-talking that may potentiate cognitive decline, identifying for the first time key steps which may be therapeutically targetable in future studies in WTC FR.

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关键词

Blood-brain barrier,Claudin-5,MMP-9,World Trade Center particulate matter,cognitive decline,neuroinflammation

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