Erratum to "Homopurine guanine-rich sequences in complex with N-methylmesoporphyrin IX form parallel G-quadruplex dimers and display a unique symmetry tetrad" [Bioorg. Med. Chem. 77 (2023) 117112].

Bioorganic & Medicinal Chemistry(2023)

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摘要
•Homopurine sequence found on human chromosome 7 folds into parallel G-quadruplexes.•NMM, a small-molecule ligand, binds and stabilizes these GQs.•GQ-NMM structures reveal a unique symmetry tetrad at the dimer interface.•The symmetry tetrad is composed of two Gs from each monomer.•NMM forms a dimer that binds to the 3′ G-tetrad of two GQ monomers on each side.•Adenines form loops stabilized via extensive π-π stacking.
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关键词
G-quadruplex,Homopurine sequences,N-methyl mesoporphyrin IX,Symmetry tetrad,Binding constant,X-ray crystallography
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