Thermoporter: a new regulatory mechanism for mitochondrial calcium uniporter activity

The mitochondrial calcium uniporter (MCU) controls mitochondrial bio-energetics, and its activity varies greatly between tissues. Here, we highlight a recently identified MCU- EMRE-UCP 1 complex, named thermoporter, in the adaptive ther-mogenesis of brown adipose tissue (BAT). The thermoporter enhances MCU activity to promote thermo-genic metabolism, demonstrating a BAT-specific regulation for MCU activity.