Bicuspid Aortic Valve-Associated Regulatory Regions Reveal GATA4 Regulation and Function During Human-Induced Pluripotent Stem Cell-Based Endothelial-Mesenchymal Transition-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology(2023)
摘要
BAV-associated distal regions regulate expression during hiPSC-based EndoMT, which in turn promotes EndoMT progression, implicating its contribution to heart valve development.
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关键词
CRISPR-Cas systems,GATA4 transcription factor,bicuspid aortic valve,heart defects,induced pluripotent stem cells
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