Design, Synthesis, Antimicrobial Screening and Docking Studies of Newer 1,4‐dihydropyridine Tethered Chalcone Hybrids

The evolution of antimicrobial drug resistance demands the development of more effective therapeutics that are more potent with reduced side effects. In the present study, we reported the design and synthesis of 1,4-dihydropyridine clubbed with chalcone hybrids in excellent yields. Further, the biological assessment of these 1-phenyl-3-dihydropyridine-prop-2-en-one chalcone hybrids as antimicrobial agents was accomplished against strains E.coli, Klebsiella pneumonia, Salmonella typhi, Staphylococcus aureus, Candida albicans (Yeast), Aspergillus niger, Alternaria solani and Fusarium oxysporum by well diffusion method in terms of zone of inhibition (in mm). Some Hybrids displayed the best anti-microbial activity against all the tested strains. A molecular docking study was performed for the most active compounds and showed the best binding pose with the highest binding score within the active sites of S. aureus DNA gyrase complexed with DNA and Lanosterol 14 alpha-demethylase. These novel products evolved as promising leads for the future development of more potent anti-microbial compounds.