Lidocaine alleviates inflammation and pruritus in atopic dermatitis by blocking different population of sensory neurons.

Na 1.8 sensory neurons play a critical role in pathogenesis of AD and lidocaine is a potential anti-inflammatory and anti-pruritic agent for AD. A precise and dissociable pattern for sensory neuronal modulation of skin inflammation and itch contributes to further understanding of pathogenesis in AD.