A new oral self-emulsifying drug delivery system improves the antileishmania efficacy of fexinidazole in vivo

Danielle Sóter do Nascimento Damasio, Patrícia Andrade Antunes,Eduardo Burgarelli Lages, Eliane de Morais Teixeira, Kátia Duarte Vital,Valbert Nascimento Cardoso,Simone Odılia Antunes Fernandes,Marta Gontijo Aguiar,Lucas Antônio Miranda Ferreira

International Journal of Pharmaceutics（2022）

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摘要

•Fexinidazole-loaded self-emulsifying drug delivery systems (FEX-SEDDS) were developed.•SEDDS formed nanoemulsions with small and homogeneous globules after dilution.•No evidence of injury to the intestinal mucosa induced by oral FEX-SEDDS.•Oral SEDDS reduced the parasite burden in Leishmania infantum-infected animals.•They can be a promising oral alternative for the treatment of leishmania visceral.

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关键词

Fexinidazole,Self-emulsifying drug release system,Visceral leishmaniasis,Intestinal permeability,Oral treatment

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