Four new chromone derivatives from the Arctic fungus Phoma muscivora CPCC 401424 and their antiviral activities

The crude extract of the Arctic fungus Phoma muscivora CPCC 401424 displayed anti-influenza A virus activities which led us to investigated their secondary metabolites. Four new chromone derivatives, phomarcticones A–D ( 1 – 4 ) and five known chromone analogs ( 5 – 9 ) have been isolated from Arctic fungus Phoma muscivora CPCC 401424. Compounds 3 and 4 possess rare sulfoxide groups in chromone derivatives. Their structures and absolute configurations were elucidated by extensive analysis of spectroscopic data, electronic circular dichroism, and comparison with reported data. Compounds 3 , 7 , and 9 showed significant anti-influenza A virus activities with the IC 50 values of 24.4, 4.2, and 2.7 μM, respectively.