Infiltrating gliomas with FGFR alterations: Histologic features, genetic alterations, and potential clinical implications.

Antonio Dono,Hanadi El Achi,Bethany E Bundrant,Puneetha S Goli,Ping Zhu,Hanim I Ozkizilkaya,Yoshua Esquenazi,Leomar Y Ballester

Cancer biomarkers : section A of Disease markers（2023）

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摘要

Histologic features correlate with FGFR alterations in IGs. FGFR3-TACC3 fusion and FGFR3 amplification are the most common FGFR alterations in IGs. FGFR alterations are a rare, but potentially viable, therapeutic target in asubset of IGs.

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关键词

FGFR1,FGFR2,FGFR3,FGFR3-TACC3,Infiltrating glioma,glioblastoma,oligodendroglioma,targeted therapy

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