GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans.

Peter Plomgaard,Jakob S Hansen,Logan K Townsend,Anders Gudiksen,Niels H Secher,Jens O Clemmesen,Rene K Støving,Jens P Goetze,David C Wright,Henriette Pilegaard

Frontiers in endocrinology（2022）

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摘要

In humans, GDF15 is a "hepatokine" which increases during exercise and is at least in part regulated by the glucagon-to-insulin ratio. Moreover, chronic energy deprivation is associated with elevated plasma GDF15, which supports that GDF15 is implicated in metabolic signalling in humans.

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关键词

anorexia nervosa,appetite,fasting,insulin resistance,liver,splanchnic bed

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