Whole-Genome Transcriptomics of PBMC to Identify Biomarkers of Early Metabolic Risk in Apparently Healthy People with Overweight-Obesity and in Normal-Weight Subjects.

Andrea Costa,Inge van der Stelt,Bàrbara Reynés,Jadwiga Konieczna,Miquel Fiol,Jaap Keijer,Andreu Palou,Dora Romaguera,Evert M van Schothorst,Paula Oliver

Molecular Nutrition & Food Research（2023）

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摘要

PBMC gene expression analysis of CXCL8 or a pool of DEGs may be used to identify early metabolic risk in an apparently healthy population regardless of their BMI, i.e., subjects with OW-OB or MONW phenotype and to apply adequate and personalized nutritional preventive strategies.

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关键词

biomarkers,metabolic risk,normal-weight obesity,obesity,peripheral blood mononuclear cells

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