Mass spectrometry-based identification of new anti-Ly and known antisynthetase autoantibodies.

Jean-Baptiste Vulsteke,Rita Derua,Sylvain Dubucquoi,Frédéric Coutant,Sebastien Sanges,David Goncalves,Greet Wuyts,Petra De Haes,Daniel Blockmans,Wim A Wuyts,Kristl G Claeys,Ellen De Langhe,Nicole Fabien,Xavier Bossuyt

Annals of the rheumatic diseases（2022）

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摘要

CARS1 is the dominant cognate ARS autoantigen of the newly discovered anti-Ly ASA specificity. Rare and common ASA specificities could be detected by both unbiased and targeted IP-MS. Unbiased and targeted IP-MS are promising methods for discovery and detection of autoantibodies, especially autoantibodies that target complex autoantigens.

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关键词

Autoantibodies,Autoimmune Diseases,Autoimmunity,Polymyositis

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