Demographic and disease‐related factors impact on cerebrospinal fluid neurofilament light chain levels in multiple sclerosis

Kamila Zondra Revendova,Chiara Starvaggi Cucuzza,Ali Manouchehrinia,Mohsen Khademi,Michal Bar,David Leppert, Elisabeth Sandberg,Russell Ouellette,Tobias Granberg,Fredrik Piehl

Brain and Behavior（2022）

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摘要

In participants with MS lacking signs of inflammatory disease activity, disease modulatory therapy reinstates an age and sex cNfL pattern similar to that of control subjects. No significant association was found between cNfL levels and clinical worsening, disability level, or MRI metrics.

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关键词

biomarker,brain atrophy,disease-modifying therapies,multiple sclerosis,neurofilament light chain,progressive multiple sclerosis,relapsing-remitting multiple sclerosis

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