Novel Irreversible Peptidic Inhibitors of Transglutaminase 2.

Nicholas J. J. Cundy, Jane Arciszewski,Eric W. J. Gates, Sydney L. L. Acton, Kyle D. D. Passley,Ernest Awoonor-Williams, Elizabeth K. K. Boyd, Nancy Xu,Elise Pierson, Catalina Fernandez-Ansieta,Marie R. R. Albert,Nicole M. R. McNeil,Gautam Adhikary,Richard L. L. Eckert,Jeffrey W. W. Keillor

RSC medicinal chemistry（2023）

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摘要

A novel peptidic scaffold was used to design a library of inhibitors that exhibit exceptional efficiency against tissue transglutaminase, providing a framework for the development of potent research tools.

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