Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway.

Lili Ji,Xiaojing Shi,Gaopin Wang,Huiping Wu,Zhansheng Hu

Folia histochemica et cytobiologica（2023）

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摘要

Our study for the first time demonstrated that STAMP2 might be able to reduce inflammation in sepsis-induced ALI by inhibiting macrophage M1 polarization through repressing NF-κB signaling activation.

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关键词

NF-κB pathway,STAMP2,inflammation,macrophage,mouse,septic acute lung injury

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