KDM1A-mediated upregulation of METTL3 ameliorates Alzheimer's disease via enhancing autophagic clearance of p-Tau through m6A-dependent regulation of STUB1

Zhanbin Tang,Jingwei Cao,Jialin Yao,Xuehui Fan,Jingkun Zhao,Mianqiao Zhao,Qiong Duan,Baichao Han,Shurong Duan

Free Radical Biology and Medicine（2023）

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摘要

KDM1A-mediated upregulation of METTL3 enhances autophagic clearance of p-Tau through m6A-dependent regulation of STUB1, thus ameliorating Alzheimer's disease. Our study provides novel mechanistic insights into AD pathogenesis and potential drug targets for AD.

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关键词

Alzheimer's disease,KDM1A,METTL3,STUB1,m6A modification,Autophagic p-Tau clearance

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