EPC infusion ameliorates acute graft-versus-host disease-related endothelial injury after allogeneic bone marrow transplantation.

Weiwei Wang, Yali Ye,Yuwei Du,Zhengqing Xu,Ke Yuan,Yizhou Wang,Seyram Yao Adzraku,Yue Li,Kailin Xu,Jianlin Qiao,Wen Ju,Lingyu Zeng

Frontiers in immunology（2022）

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摘要

EPC infusion can mobilize to affected endothelium to decrease the infiltration of T cells and pathological endothelial activation contributing to ameliorating the damage of endothelium. EPC infusion combined with bone marrow transplantation might be a perspective strategy for the prevention and treatment of aGVHD.

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关键词

acute graft-versus-host disease,endothelial cell activation,endothelial injury,endothelial progenitor cell,endothelium

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