Identification of glioblastoma-specific antigens expressed in patient-derived tumor cells as candidate targets for chimeric antigen receptor T cell therapy.

Tomoyoshi Nakagawa,Noriyuki Kijima,Kana Hasegawa,Shunya Ikeda,Moto Yaga, Tansri Wibowo, Tetsuro Tachi, Hideki Kuroda,Ryuichi Hirayama,Yoshiko Okita,Manabu Kinoshita,Naoki Kagawa,Yonehiro Kanemura,Naoki Hosen,Haruhiko Kishima

Neuro-oncology advances（2023）

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摘要

Cancer-specific targets for CAR-T cells were identified using a mAb library raised against primary GBM tumor cells from a patient. We identified a GBM-specific mAb and its antigen. More mAbs against various GBM samples and novel target antigens are expected to be identified using this strategy.

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关键词

B7-H3,CAR-T cell therapy,expression cloning,glioblastoma (GBM),monoclonal antibody

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