Copper-promoted Dehydrosulfurative Carbon-Nitrogen Cross-Coupling with Concomitant Aromatization for Synthesis of 2-Aminopyrimidines.
RSC advances(2023)
摘要
Copper-promoted dehydrosulfurative C-N cross-coupling of 3,4-dihydropyrimidin-1H-2-thione with amine accompanied by concomitant aromatization to generate 2-aryl(alkyl)aminopyrimidine derivatives is described. The reaction proceeded well with a wide range of thiono substrates and aryl/aliphatic amines as the coupling partners, offering efficient access to biologically and pharmacologically valuable 2-aryl(alkyl)aminopyrimidines with rapid diversification.
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