Docosahexaenoic acid-acylated astaxanthin monoester ameliorates chronic high-fat diet-induced autophagy dysfunction via ULK1 pathway in the hypothalamus of mice.

Xiaoxu Wang, Peixu Cong, Xincen Wang,Zhigao Wang, Bin Liu, Changhu Xue,Jie Xu

Journal of the science of food and agriculture（2023）

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摘要

This study identified AST-DHA as an enhancer of autophagy that plays a beneficial role in restoring hypothalamic autophagy, and as a new potential therapeutic agent against HFD-induced obesity. This article is protected by copyright. All rights reserved.

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关键词

Astaxanthin,High-fat diet,Hypothalamic autophagy,POMC,α-MSH

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