Pharmacokinetics of zanamivir in critically ill patients undergoing continuous venovenous hemofiltration.

André Wieringa,Peter Gj Ter Horst,GertJan Hj Wagenvoort,Birgit Cp Koch,Jasper J Haringman

Antiviral therapy（2023）

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摘要

Zanamivir is well cleared by CVVH. In absence of the possibility for therapeutic drug monitoring, the ultrafiltration rate seems as a good surrogate parameter to estimate the CL and may help guide the dosing of zanamivir.

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关键词

CRRT,ICU,antiviral therapy,influenza,neuraminidase inhibitor,pharmacokinetics,sieving coefficient,zanamivir

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