Injectable Host-Guest supramolecular hydrogel Co-Delivers hydrophobic and hydrophilic agents for enhanced wound healing

Jie Xu,Kangning Wang,Yanyan Li,Yue Li,Bingxin Li,Hangqi Luo,Huiling Shi,Xueran Guan,Ting Zhang,Yixiao Sun, Feng Chen,Huacheng He,Junwen Zhang,Lin Cai,Wenxiang Song,Jiang Wu,Xiaokun Li

Chemical Engineering Journal（2023）

引用 5|浏览19

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摘要

•A simple injectable hydrogel is formed through the host–guest interaction between F127 nanoparticle and α-CD.•The hydrogel simultaneously encapsulates hydrophilic bFGF and hydrophobic anti-inflammatory drug PNCB.•Both bFGF and PNCB can be released from the hydrogel in a controlled manner.•The hydrogel effectively promotes the skin wound healing in vivo by taking advantages of bFGF and PNCB.

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关键词

Host-guest,Growth factor,Inflammation,Cyclodextrin,Wound healing

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