RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix Metalloproteinase-9 in Gastric Cancer.

Satoshi Nakamura,Masato Kitazawa,Yusuke Miyagawa,Makoto Koyama,Satoru Miyazaki,Nao Hondo,Futoshi Muranaka,Shigeo Tokumaru,Yuta Yamamoto,Takehito Ehara,Tomio Matsumura,Michiko Takeoka,Yuji Soejima

Technology in cancer research & treatment（2023）

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摘要

Overall, our findings indicate that RhoA G17E is associated with Vav1 and promoted cancer invasion via matrix metalloproteinase -9 in gastric cancer cells. Thus, RhoA G17E/Vav1 signaling in diffuse gastric cancer may be a useful therapeutic target.

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关键词

RhoA,Vav1,diffuse gastric cancer,malignant phenotype,matrix metalloproteinase −9

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