Engineering the Modular Receptor-Binding Proteins of Klebsiella Phages Switches Their Capsule Serotype Specificity

Agnieszka Latka,Sebastien Lemire,Dennis Grimon,Dorien Dams,Barbara Maciejewska,Timothy Lu,Zuzanna Drulis-Kawa,Yves Briers

mBio（2021）

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摘要

The antimicrobial resistance crisis has rekindled interest in bacteriophage therapy. Phages have been studied over a century as therapeutics to treat bacterial infections, but one of the biggest challenges for the use of phages in therapeutic interventions remains their high specificity.

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