Plasmodium falciparum Plasmepsin 2 Duplications, West Africa

Juliana Inoue,Miguel Silva,Bakary Fofana,Kassim Sanogo,Andreas Mårtensson,Issaka Sagara,Anders Björkman,Maria Isabel Veiga,Pedro Eduardo Ferreira,Abdoulaye Djimde,José Pedro Gil

Emerging Infectious Diseases（2018）

引用 15|浏览7

暂无评分

摘要

Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.

查看译文

关键词

malaria,piperaquine,resistance,Plasmodium falciparum,plasmepsin 2,Pfpm2

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要