Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Wayne Vuong,Muhammad Bashir Khan,Conrad Fischer,Elena Arutyunova,Tess Lamer,Justin Shields,Holly A. Saffran,Ryan T. McKay,Marco J. van Belkum,Michael A. Joyce,Howard S. Young,D. Lorne Tyrrell,John C. Vederas,M. Joanne Lemieux

Nature Communications（2020）

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摘要

Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were originally used to treat feline coronavirus infection.

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