Phytochemicals and in-vitro antioxidant activity analysis of Aloe vera by-products (skin) in different solvent extract

Aloe vera (A. vera), one of the most popular medicinal plants, is regularly used throughout the world to prevent or treat cancer, metabolic problems, cardiovascular diseases, and skin concerns. In this study, we investigated the antioxidant properties of A. vera skin extract, which are neglected during gel extraction. In the current work, we investigated the phytochemical and antioxidant profiles of an A. vera by-product using three different solvents and two different drying methods. The findings of the study showed that sample drying and solvent extraction methods had a significant impact on the phytochemical content and in vitro antioxidant activity. The oven-dried sample of the A. vera by-product contained more phytochemicals, antioxidants, and in vitro activity than the sun-dried sample does. The study of solvent effects also indicated that an acidified methanolic solvent for A. vera by -products was the most effective extraction medium for phytochemicals and antioxidants than methanolic or aqueous ethanolic extract. Additionally, the comparison of solvent effects in the assessment of antioxidant ac-tivity in various in vitro models was investigated, and findings revealed that the maximum antioxidant activity and radical scavenging activity were found in oven-dried acidified methanolic (O-AM) extracts. The principal component analysis (PCA) has shown that the biggest variation was 87.3% and O-AM has the highest contri-bution to the dimension 1 (68.7%) in the PCA. These findings will spur attempts to describe the bioactivities of A. vera by-products and increase their application in the cosmetics, food, and healthcare sectors.