Safety, tolerability, and pharmacokinetics of cariprazine in pediatric patients with asd

Paul Yeung,Kimball A. Johnson,Robert Riesenberg,Amelia Orejudos,Todd Riccobene,Hari V. Kalluri,Paul Malik,Shane Varughese,Robert L. Findling

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY（2022）

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摘要

Cariprazine is a dopamine D3/D2 and serotonin 5-HT1A receptor partial agonist. This study evaluated the safety, tolerability, pharmacokinetics (PK), and exploratory efficacy of cariprazine and its 2 major active metabolites, desmethyl cariprazine (DCAR) and didesmethyl cariprazine (DDCAR) in pediatric patients with ASD.

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关键词

cariprazine,pharmacokinetics,pediatric patients,asd

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