Steroidal saponins from the roots of Polygonatum odoratum and their inhibitory effects against pancreatic lipase

Twenty steroidal saponins were isolated from the water extract of fresh fibrous roots of Polygonatum odoratum (Mill.) Druce, of which seven were new compounds (1-7) along with thirteen known compounds (8-20). Their chemical structures were elucidated by extensive spectroscopic and chemical techniques. All isolated compounds were evaluated for porcine pancreatic lipase inhibitory activity. Compounds 9 and 10 showed inhibitory effects with IC50 values of 201.90 ± 0.036 μM and 151.20 ± 0.058 μM (positive control orlistat; 2.82 ± 0.060 μM).