Myeloid Progenitor Inhibitory Factor-1 (CCL23) Inhibits Lung Leukocyte Recruitment in a Primate Cardiopulmonary Bypass-Induced Pulmonary Ischaemia Model.

Yukinobu Goto,Yuji Hiramatsu,Naohide Ageyama,Bryan J Mathis,Naoki Maki,Muneaki Matsubara,Yoshiaki Inoue,Yukio Sato

Heart, lung & circulation（2023）

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摘要

CCL23 treatment slows turnover of PMN and MO progenitors in BM and suppresses their circulatory release and lung recruitment. CCL23 has inhibitory effects specifically on the CPB-induced BM response and could hold value for preventing CPB-induced lung injury.

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关键词

Animal model,CCL23,CPB,Cardiopulmonary bypass,Lung,Stem cells

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