Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib.

Chen Yang, Tao Lu, Ming Liu,Xiaoqing Yuan, Desheng Li,Jiayu Zhang,Ling Zhou,Maolei Xu

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

Our findings imply that tiliroside is a potent TBK1 inhibitor and a candidate natural anti-cancer product that could function as a sensitizer of sorafenib in HCC treatment by targeting TBK1 to induce ferroptosis.

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关键词

Ferroptosis,Hepatocellular carcinoma,Sorafenib resistance,TANK-binding kinase 1,Tiliroside

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