Effect of allogeneic adipose tissue-derived mesenchymal stromal cell treatment in chronic ischaemic heart failure with reduced ejection fraction - the SCIENCE trial.
European journal of heart failure（2023）
摘要
The SCIENCE trial demonstrated safety of intramyocardial allogeneic CSCC_ASC therapy in patients with chronic HFrEF. However, it was not possible to improve the pre-defined endpoints and induce restoration of cardiac function or clinical symptoms.
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关键词
Adipose tissue derived-mesenchymal stromal cells,Allogeneic therapy,Clinical trial,Heart failure,Ischaemic cardiomyopathy,Stem cells
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