A Theranostic Probe for Promotion of Skin Wound Healing by Exudate-Triggered H 2 S Release with Self-Monitoring Ability.

Hydrogen sulfide (HS) as an endogenous gasotransmitter plays a critical role in promotion of wound healing. However, the current HS release system lacks the monitoring ability, which may lead to insufficient or overdose release of HS and serious side effects. Herein, we develop a self-monitoring theranostic probe TPATCF-S, which can quickly release HS under water stimuli associated with a self-monitoring ability by a color change from colorless to deep blue. With a full thickness dermal defect as a model, the TPATCF-S absorbed on alginate dressings can be used for wound exudate-responsive release of HS to efficiently promote skin wound healing.